This guest article was written by my friend Debbie Graefer, L.Ac. MTOM
Licensed Acupuncturist and Masters in Traditional Oriental Medicine. Debbie is the mastermind behind the great site called GallbladderAttack.com. If you have ever searched online for gallbladder information (like symptoms, attack, foods to avoid, etc), you probably came across her site.
I’ve asked her is she could write and educate us on the very important topic of the connection between the gallbladder and our hormonal balance. You see, I’ve seen many women after having their gallbladder removed develop many hormonal problems. It seems that Western medicine is failing us again – liberally and mindlessly treating the gallbladder like a useless organ that we can easily disposed of to address an immediate pain. At the cost of other issues developing further down the road – only to be treated with more meds.
Here is what Debbie has to say.
What and where is the gallbladder
Although digestive symptoms may be brought on by any number of things, what is often overlooked is the gallbladder. The gallbladder is a small organ that sits under the liver on the right side of the rib cage and stores liquid bile which is used to digest fats. Even without eating a fatty diet, the gallbladder can begin to act up with symptoms ranging from pain or tenderness under the right rib cage, pain between the shoulder blades, indigestion especially after fatty foods, a feeling of fullness, gas, bloating, nausea, vomiting, burping and the list goes on. For symptoms of a full-on gallbladder attack, visit GallbladderAttack.com.
When the idea of gallbladder problems is first mentioned, one automatically jumps to the conclusion of gallstones. While gallstones are the most common cause of these digestive symptoms, they are not the only one. Symptoms occur even without the presence of stones, usually brought on by a sluggish or low-functioning gallbladder. In fact, this low-functioning probably allows the gallstones to form in the first place.
The gallbladder and hormone connection
Hormones are always involved in one way or another. A hormone is simply a protein that is used to deliver a message or a command from one part of the body to another, usually initiating or terminating a function. Considering how many functions are going on in the body at all times, it will not be so surprising to learn that there are more than 50 different hormones and several that are involved in the proper functioning of the gallbladder. And there are others yet that affect it less directly. This article will discuss only a few of them.
Motilin is a hormone found in the cells of the intestines. It is released in response to fat intake or acidity in the small intestine. Motilin initiates the contraction of the gallbladder to induce its emptying of bile. In pregnancy, motilin is found to be profoundly reduced, especially in the 2nd and 3rd trimester. It is postulated that this may contribute to gastrointestinal hypo-motility (or a slow-moving GI tract) which symptoms include constipation, indigestion and gallbladder disease, all of which are quite prevalent during pregnancy.
Melatonin is a hormone that is secreted in the dark and stops secreting in response to light. It regulates not only sleep, but your whole biological clock. Traveling through several time zones can really throw melatonin production out of balance. But did you know that melatonin may also inhibit gallstone formation, reduce the cholesterol in the bile by inhibiting its absorption as well as increasing the conversion of cholesterol into bile salts? Studies show that melatonin therapy could possibly assist in the recovery of the neuromuscular function of the gallbladder wall during or following acute gallbladder inflammation, allowing it to contract more fully.
Cholecystokinin or CCK is a hormone that initiates gallbladder contraction and pancreatic enzyme secretion. If you have had a HIDA scan to test for a low-functioning gallbladder, they will have injected CCK to initiate gallbladder contraction and measure the amount of bile that is secreted. Normal is from 32-44%.
Thyroxin (also spelled thyroxine) is a thyroid hormone which helps to regulate metabolism. Low thyroxin levels or low thyroid function is connected with low gallbladder functioning as well as low bile flow, both which contribute to the formation of gallstones.
The sphincter of Oddi, which controls the release of bile into the small intestine, has receptor sites for thyroid hormones, and the sphincter relaxes in response to the thyroxin. A relaxed sphincter of Oddi allows for free flow of bile which is less conducive to the formation of gallstones. Lack of thyroxin such as found in hypothyroidism could result in a contracted sphincter. This phenomenon is thought to contribute to the formation of CBD or common bile duct stones that form from the bile left sitting in the duct.
Interested in learning more about how to find hormonal balance with proper nutrition? Join our exclusive full program viewing below:
Gallbladder Surgery and Its Aftermath
There are several common side-effects following gallbladder surgery which can be read about here. It is the hormone related side-effects that I’d like to touch on as they are not generally acknowledged.
It was complaints from women, mostly, following gallbladder surgery that prompted my research into the why. Comments that their body was thrown out of balance or that “things have just not been the same since” as well as “weight gain that I’ve never had an issue with before.”
Some of the reasons could be coincidental, or hitting at the same time as surgery such as age-related peri-menopausal symptoms, insulin resistance or poor eating habits catching up with you. But what is more likely is that the stress from both the gallbladder disease and the surgery are triggering hormonal imbalances all over the place.
Everyone will react to an affront like surgery differently, but in everyone, surgery will stimulate a major stress response that is accompanied by both hormonal and metabolic changes. It activates the sympathetic nervous system (SNS), the hypothalamic-pituitary axis ( HPA), and the adrenal cortex. The hormones ACTH, catecholamine, cortisol and glucagon all play major roles in regulating the stress response.
Specific markers increased in gallbladder surgery are somatropin (growth hormone), CRP (acute inflammatory markers) and cortisol (the adrenal hormone involved both in stress and in reducing inflammation).
Somatropin is a protein anabolic hormone which basically means when protein cells are destroyed due to surgery, growth hormone is released in an attempt to rebuild or create new protein cells. There have been studies done showing that people given somatropin intravenously following gallbladder surgery recuperate from the surgery faster. To date this is not a practice that is used but it would be nice!
Inflammation can cause a cascade of hormonal havoc which people will react to and recover from differently. It can knock some people out for weeks to months, depending on their underlying health. Others are not affected. Also know that something as stressful as a surgery can bring on a latent condition such as Hashimoto’s and make it express.
For those of you who lost your gallbladder to surgery, this article discussed several things you can do to steer your health back on track; improving your digestion and hormonal balance.
Gallbladder and Sex Hormones (like estrogen, progesterone)
It has long been known that both pregnancy, long-term oral contraceptive use and hormone replacement therapy (HRT) contribute to the formation of gallstones and the accompanying symptoms of pain, indigestion, burping, gas and bloating, and possibly nausea. But what are the underlying mechanisms involved?
Estrogen and progesterone (known as the female hormones) when present in excess cause three separate alterations in the biliary (bile) system:
- a higher ratio of cholesterol to bile salts – also called super saturation of bile
- a higher propensity of the bile to aggregate or clump together – or stickiness of bile
- a lower than normal functioning of gallbladder emptying – leaving bile sitting stagnant in the gallbladder sac
Note from Magdalena: On the other hand, the bile helps the liver to excrete hormones like excess estrogen and its harmful metabolites. That explains why women who have their gallbladders removed often suffer from symptoms of estrogen dominance a few months after the surgery.
Counteracting the effects of the female hormones on the biliary tree
There are always choices that can help – pregnancy excluded.
- Choosing contraceptive measures other than hormones.
- Chinese and western herbs including adaptogens, nutrients and adrenal support to manage the symptoms of both menopause and peri-menopause.
- Support bile thinning, bile flow and liver detoxification.
These can make a huge difference when taken in tandem with any increased presence of hormones. All of these methods, excluding the liver detox can be used during pregnancy and nursing.
What kind of diet helps the gallbladder and bile as well as hormonal balance?
This is a two part process – what to avoid and what to include. General principles are listed here but
for a list of specific gallbladder-friendly foods, foods that trigger gallbladder symptoms, or to download our 30 day menu plans, check out the gallbladder diet page.
Avoid:
- all common allergens such as gluten, dairy, eggs and soy
- all refined foods – sugar, flour
- trans fats such as fried foods, hydrogenated and partially hydrogenated oils
- red meats which are inflammatory
Include:
- organic foods with a focus on fresh vegetables and fruits
- small amounts of complex carbohydrates such as rice
- moderate amounts of wild-caught (not farmed) fish
- good oils such as olive oil, fish oils, coconut oil – all in small amounts
DO NOT OVEREAT – EVER!
It’s the worst thing for your digestion and for your health overall. And it can trigger gallbladder attacks if you have a gallbladder problem.
Regardless of which hormones are off balance within you, as you work to harmonize those, begin now to address your specific gallbladder condition as well. First of all, take into consideration what may be the cause of your gallbladder symptoms. Address the ones that you are able to. And simultaneously, eat foods and take products that help to thin and gently move the bile. And apply castor oil packs over the abdomen which research shows have the ability to reduce inflammation in the area and which may also help you with much-needed relaxation and stress reduction.
Deborah Graefer is a Licensed Acupuncturist with a Masters in Traditional Oriental Medicine. She has been specializing in gallbladder and other digestive issues since 2001 with the launching of her website GallbladderAttack.com. She consults with people who are looking for answers or for alternatives for their symptoms. You can read more about her story here.
I am 71. 6 weeks following gallbladder removal , I had severe pain in my left breast that lasted 2 weeks. Has anyone else experienced this?
Apologies fo rtypos, also the malfuctioning SHIFT key on my keyboard means I have problems with capitals.. as if panic attacks weren’t enough! Lol. btw I am 64 years old, and ptherwise in good health, considering. 🙂
Cholecystokinin secretion after Cholecystectomy?
Hello, i had my gallbladder out in march 2017, by January 2018 I began having the most horrific panic attacks, and i mean absolute terror, with closing of my throat, dry mouth and a sense of all-encompassign terror in my solar plexus.
Fortunately I knew straight away that this was a physical ersponse, because they only happened after meals, and if I di d not eat they did not happen at all.
So I read-up on panic attacks and found i had none of the other symptoms often associated with panic attacks – sweating, tachichardia, tremors – and wondered about the connection between the absence of my gallbladder and these episodes.
Researching in more depth revealed tha the gallbladder is connected to the solar plexus via the upper mesenteric nerve, and that one ofthe hormones you mention, Cholecystokinin, is both, panicogenic and anxiogenic.
This led me to conclude that my attacks were of purely physical origin and i asked my GP for help. though she did not comment on my hypothesis – of a link between the attaks and my Cholecystectomy – as soon as she heard that this was effectively nerve pain, she presecribed Amitriptyline, 10 mg in the evening.
The treatment works, mostly, and I only suffer very light and brief episodes now, mostly after eating. Only, I am not happy to be on such a heavy drug, sith so many possible side effects over time, and I wonder also how it will interact with my Thyroxine, that I take for my Hypothyroidism (100mg a day).
I wondered whether others experienced the same issues, and would warn them not to allow their physicians to put them on heavy medication. i have read of patients being put on heavy doses of antidepressants and becoming very unwell and even addicted.
Thank you for your kind attention.
I have been going through menopause for 4 years ,on HRT for 3 years. One week ago l had gall bladder removed and yesterday my period resumed. Is this normal. Will l go through the whole hot flushes etc again or is it just a shock to the system.
Oh i should add that i take oxbile wirh my food… i cit back when i feel nauseous from it but i also take probiotics / digestive enzimes… and milk thistle. Which seems to help some. But still i have not found any help with the deficiencies
I haven’t had my period in over a year.
Hi, i’m so glad i found this article… ive been searching for something that matches what i’m experiencing. I don’t know what or where to turn… i was against surgery feom the start. 10 yrs ago when i was 6 months pregnant, i went to the er for horrible pain i was having. Right away i was told i need my gall bladder removed it was so sudden, but the next day i was recovering from the surgery. That 48 hrs from when i went in through that night ( orders to prepare me for surgery the next morning) till i was able to go home. But the only thing i could focus on was my baby… i was informed that i need to have the surgery for my better health and the baby will be fine. I was against the surgery and i guess ever since, in a way i feel like i was cheated out of options. (I literally tear up everytime i think about it) every day i have to live in hell without a gall bladder. My health has plummeted and i fear what is coming for me in the future. I’m 33 yrs old. I used to be healthy. Active fit. I still dont understand why (at 6 months pregnant) i had to have my gall bladder removed. I gained so much wait overnight it seems. In 2015 i was 135 lbs. And now i am 220. I cant eat anything without rushing to the bathroom, and yes sometimes im not lucky enough to make it intime. Tge noises that my stomach makes are embarrasing. I would rather accidently let out a little air in public then sit in a public place while my uncontrollable stomach makes the noises that are just as bad, but contstant. Im losing my hair… i have horrible acne now. And just the other day, even my dentist asked me if i have had my hormones checked, because i have had so much bone loss in my upper jaw that i am now facing losing my teeth. My life is a nightmare that started with the simple act of going to the hospital & not over the pain necessarily but more as a precaution do to the fact i was pregnant. I know whats done is done. But what do i do. Ive made lifestyle changes and i need a dr who will listen to me. so far… i just find doctors that want me to make more changes to rule out other possible reasons or condition but what about my deficiency in my health and nutrition i suffer with in the mean time . Yesterday i had one dr suggest i start juicing. & I am sorry for venting like a lunatic… but finding this website feels like i just found the end of the internet. Please Any insight will help.
I had my gallbladder removed 10 years ago, I am now 54. Menopause begin within weeks after removal along with digestive problems. Even though I have made a lot of positive changes into my lifestyle since, nothing has changed the severe hot flashes that I have been experiencing shortly after removal. The ability to cope with the smallest amount of stress has been forever changed since surgery. I wish I would have been more informed about the connection of hormones after gallbladder surgery as I would have not done it.
Is there anything that can help the hot flashes? Any help would be appreciated. Thank you
Dont ever ever get your gall bladder removed. My Mom did. Her life ruined with diarhea attacks. Me too. Diarhea uncontrolable diarhea… Miserable life. And Drs should be sued for misinformation. I live in Mexico. My maids told me you disdolve the stones with Jaimica. a drink made from Hibiscus…I want to get a gall bladder transplant!
I finally found Questin and Smecta from my Monaco Dr. It has stopped the diarehea…
Ask your Pharmacy about it. They know much more about meds than Drs do!
I believe that is not true. There are water soluble vitamins and fat soluble vitamins (such as Vitamin D and a few others). If you do not have a gallbladder you should be able to absorb the water soluble ones just fine. BUT, since you do not have a gallbladder, you probably will have trouble absorbing fat soluble vitamins and end up with a vitamin D deficiency or any other fat soluble vitamin deficiency as well. You will have trouble absorbing fat soluble vitamins because your fat digesting ability has been hindered. The solution is to take digestive enzymes with food and the multi vitamin. That is my advice. I had my gallbladder removed and I have a vitamin D deficiency because of it.
Agreed. I noticed that I was not absorbing A,K,D,E etc. My eyesight tanked. My periods just stopped. Weight gain, etc. My skin suffered. It’s as if I am instantly older.
I agree with you totally, I too feel like I was deceived. I wish I wouldn’t have had the surgery. It just causes more problems. I wish there was something I could do to stop it. Sorry about your friend.
Without a Gallbladder but found something that HELPED!
Gallbladder removed 10 month ago. Never had digestive issues. Once removed, I began to feel bloated, constipated, etc. Asked Doc to prescribe something that would help digest food. They were no help. I eat “CLEAN” always have and always will. Did my own research, and just stumbled on this product. What attracted me to this product was soy free, etc. free. Which you want in any supplement. Started taken this product for 4 days now and I feel amazing. No gas, no bloat and oddly – NOT CRAVING FOR FOOD? Is this possible. I read that this product would help with Pancreatic issues resulting from a missing gallbladder. But never imagined that it would curb my CRAVINGS. Anyone else experience this? I had put on weight since surgery, but now feel like my weight will come down since my food is ACTUALLY NOW DIGESTING! Anyone experience this side effect, please email me. Would love to hear your experience. Thank you. Oh and I workout like faithfully. Aging gracefully!
Anna on Aug 2, 2018
What is the product your taking?
Sorry I forgot to include the product name:
From The Vitamin Shoppe- their brand_ multi-enzyme. I take 4 with each meal and 1 with coffee. (milk no sugar).
1 cup a day of coffee.
I don’t drink nor smoke and workout
I found i gained weight after surgery for sure. but I think perhaps why so many people may have issues, is perhaps their diet wasn’t clean to begin with. Just my observation. I eat clean and exercise. I am 54 yr old and for sure maintain a healthy lifestyle with these supplements. Anyone tried taking the multi enzyme? without any filers of course.
I’ve been suffering from gallbladder attacks after pregnancy. Went to the ER and they said I HAD to get my gallbladder removed. I cut out all dairy from my diet. I should also mention I have celiac disease. I was eating a gluten free diet and after still having issues I went grain free. Got a little better but still had attacks and still was dealing with inflammation, bloating and water weight. I live in a very isolated, rural area and food is hard to get around here (well, anything unprocessed and fresh or froze). I was eating red meat (grassfed) and spinach because spinach was the only thing we could get at the store. Eventually the spinach was becoming difficult to find or it was rotten. Out of necessity, because we couldn’t get anything else at the store, I started eating only red meat and supplementing with ox bile (ancestral supplements), my inflammation has gone away, no water weight and I generally feel better. I’ve noticed that if I do have an attack, it’s due to high stress! I’ve seen other people claim they’ve healed their gallbladder with a high fat (healthy animal fat) and mea. There’s also a study, in Sweden I believe, where they healed gallbladders with a high fat diet. I’m not ready to get rid of my little buddy, gallbladder, and I’m willing to try whatever to get healthy and not go through surgery!
Hi I recently had my appendix move along with one ovary during an emergency appendectomy. The surgeon was concerned that my ovary was the cause of my pain. It looked inflamed like a cyst had ruptured. I was glad he removed it because I think I was having issues with cysts for years. Now I am having gallbladder issues ironically after my ovary has been removed which I never had before. I don’t got the profile for someone with gallbladder disease. Doctors keep telling me stay away from fatty foods when I’ve been eating clean and organic for the past 5 years. I looked further that other foods cause gallbladder attacks which I’m avoiding now such as gluten, dairy, eggs and red meat. I’m going to do the gallbladder diet. Is there anything else I should do like get my hormones checked to see if that helps alleviate my gallbladder symptoms? I’ve already been to the ER once for severe symptoms.
Hi Heather,
Good job on what you have done already! Here is a link to find a functional practitioner in your area and included in there is a link to order your own lab work too https://hormonesbalance.com/articles/find-supportive-doctor/. ~Deanna HB Team
Heather, I would recommend having your hormones checked as soon as possible. Ovarian cysts are consistent with estrogen dominance in most women. High estrogen levels can cause gall bladder symptoms as well. Considering your history with ovarian cysts I think hormones could be at play here.
Thank you for the support here Jenny V ~Deanna HB Team
Your liver does that hun. So long as your not drinking alcohol, not eating inflammatory food like A1 milk, you can take Vitamins. Try and get them from food and the sun where you can
Hi Simba,
The liver and gall bladder work closely together. These detoxification pathways can become clogged by many factors including environmental toxins and body care products. It goes deeper than food and vitamins can cover. Thank you for being here and learning.
Kindly, Angela HB Team
Thank you Julie!
I had my gallbladder removed 4 weeks postpartum. It’s been 4 years now and I have been battling anxiety and some panic attacks since the surgery. I was diagnosed with postpartum anxiety and went on 50mg setraline for a year after my baby was born. I went off the setraline for 3 years but have struggled badly and needed to go back on setraline for anxiety recently. I felt like I was swimming while walking, so dizzy I was afraid of falling down while walking. The anxiety heightens during week 3 of my menstral cycle. I constantly worry about everything and it’s worse in the mornings. I really think I have a hormonal imbalance. What blood tests should I start with? I don’t want to be on anxiety meds if something else is wrong?
Removed at 36 – 8 months ago always been slim and very active, I’ve experienced anxiety and the weight is coming on, I’m still very active and eat very clean.
Hi Tiffany, I had a similar situation post partum (minus the gall bladder removal) and have been on oral progesterone bio identical for the last 10 years. You have your progesterone tested 3 days post ovulation and see what the number is. Low progesterone will cause anxiety and it is very challenging to feel anxious all the time. Once I got on progesterone my anxiety went away ;). Let me know if I can help you further.
Hi Julie! Thank you for the advice!!! I keep saying that once my body knows it’s mot pregnant right after ovulation, I feel the anxiety kick in like clockwork. I just thought I was being silly! This really could be a problem?! I will talk to my doctor. Did your GP doc help you or your gynecologist?
Tiffany, I go to a functional medicine place with a nurse practitioner that is dialed in on hormones. Unfortunately, most Gyns are not great with hormones. Try to find a functional medicine doc that is good with hormones where you live.
Julie, would you mind sharing the name and office that you found a doctor who specializes in hormones? I need to see a specialist. thank you!
Maggie, here is a link to find a doctor in your area https://hormonesbalance.com/articles/find-supportive-doctor/ ~Deanna HB Team
I am 53 and in perimenopause. My gall bladder was removed when I was in my 20s. I have been experiencing flatulence and general indigestion pain and ‘pop’ movements in my chest area in recent weeks. Do you please have any advice for me. The only medication I am on is Ramipril 5mg. Thanks so much.
Hi Angela, thank you for your question. Check out the last part of the article about what kind of foods to eat. That is a good place to start. Additionally, you may want to try digestive enzymes with each meal and consider a probiotic. Hope that helps!
Hi Denise
After doing some research I think having my gall bladder removed has contributed to my hormone positive breast cancer which spread to six lymph nodes. After chemo and radiation I am taking tamoxifen and about to start aromatose inhibitors. What can be done now to help eliminate excess oestrogen from my body without the help of a gall bladder?
Thankyou
Thank you for your question. There are alot of things that can still be done with the gallbladder. It is important to keep the liver working in tip top shape. The Cooking for Balance free workshop will teach you about the Hormone Balance ecosystem. You can register here at https://hormonesbalance.com/cfb I hope you will join us.
Tierri,
Thank you for your question. There are alot of things that can still be done with the gallbladder. It is important to keep the liver working in tip top shape. The Cooking for Balance free workshop will teach you about the Hormone Balance ecosystem. You can register here at hormonesbalance.com I hope you will join us.
HI Tierri, lots can be still done without the gallbladder! You will want to check out http://www.cookingforbalance.com to learn more about the body’s ecosystem.
I as well had my gall bladder removed, probably 20 years ago, thank goodness, that was so painful to go thru the many “attacks” I had for a few years before I found out the cause, I did have some weight gain, I am now 64, and the best thing I did for myself was the “whole 30”, it made me more in tune with my body, was able to lose that last 10 lbs, that was hanging in there, now I still continue with a paleo diet, but am always open to learning MORE! I think the key is to eat clean and stay active!
Hi Doris,
Such a good story to share. Thank you for giving us your thoughts.
I had my gallbladder removed when I was 20 years old. I am now 53 with insulin resistance, 30 pounds overweight, through menopause and have always had a hard time controlling my weight since I was about 30 yrs old. At 40 I also had part of my colon removed. I eat fairly well but do consume to much sugar at times. I am looking for any suggestions you may have on essential oils that may help. I feel that some of these issues may stem from loosing my gallbladder at such a young age. I would be grateful for any suggestions or help you can offer. Thank you
Wow Denise, your story is pretty much my story. Gallbladder removed at 21, now 54 and through menopause. I have managed to put on an extra 100+ pounds, extremely discouraging….I watched the Hormone Balancing webinar and am going to check the Thyroid webinar, it’s obviously time to stop eating dessert every day and get moving!!
We have been thinking about you Penelope! How are you doing now? ~Deanna HB Team
Hi Denise,
Thank you for sharing your story.
I don’t find that EOs alone can help solve issues if the biggest thing you are putting into your body – food, is not well taken care of. I explain at length the difference between “eating well and eating right for YOU” in this free workshop: http://www.cookingforbalance.com. I hope you get a chance to listen in and decide what else to do to improve your health. 🙂