What You Will Learn in This Article
- DIM – the Estrogen Dominance supplement
- Some benefits of DIM
- When DIM stops working… what’s going on?
- How sulforaphane works with DIM
- How calcium D-glucarate works with DIM
- Overcome Estrogen Dominance with help from this kit
- Who can benefit from the Estrogen Reset Kit
- Where to start
If you’ve spent much time on this website, you may have noticed that we dedicated most of our resources to help women address Estrogen Dominance. If you are not familiar with this hormonal condition, start by either reading my book Overcoming Estrogen Dominance, or read this comprehensive article for a great overview of this condition. There, you’ll also find a FREE assessment you can take to help you figure out whether you’re likely to be estrogen dominant.
The short version is that Estrogen Dominance is an imbalance of one or more of the following:
- Estrogen and progesterone
- Protective/”good” (E3) and aggressive/”bad” (E1 and E2) estrogens.
- Too many “Dirty” metabolites created from breaking down estrone (E1)
Many women have been advised or have found recommendations from books or online to take a supplement called DIM. It’s one of the top recommended supplements for overcoming estrogen dominance.
In fact, its effects on estrogen are the main reason those with a higher risk for breast- or other estrogen-sensitive cancers are advised to eat more broccoli and other Brassica-family vegetables. (1) DIM is a great supplement that works well for women of all ages in reducing symptoms of estrogen dominance. However, many women report that it works really great for a while, but then it stops.
So, what happened? What’s missing? Stay tuned – that’s what we’ll cover in this article.
DIM: The “Estrogen Buster”
DIM stands for di-indolyl-methane. DIM comes from indole-3-carbinol, which is a compound naturally found in cruciferous vegetables such as broccoli, cauliflower, Brussels sprouts, cabbage, and collards. When these foods reach the stomach, indole-3-carbinol is broken down by the stomach acid. DIM is then released as a by-product. (2)
However, the amount of DIM you get from digesting a serving or two of broccoli isn’t going to be enough if you’re in a state of estrogen overload. You’d need to eat about 6 pounds of these vegetables a day to get a therapeutic dose of DIM. (3)
That’s where supplements come in. A clinical trial published in the journal Nutrition and Cancer has reported that it takes a dosage of about 100 mg of DIM to have any effect on estrogen dominance. (4)
While taking indole-3-carbinol (I3C) can be helpful for some women, I do not recommend taking supplemental I3C for two reasons:
- I3C needs cofactors in the stomach to get converted to DIM. Then it’s the DIM that does the work. (3) Most people have low stomach acid and the conversion may not happen.
- In the process of improving 2:16 estrogen metabolism, I3C also increases 4-hydroxy estrone, which is linked to breast, ovarian, and uterine cancers in some women. (5)
The conclusion is: DIM works a lot better, and it does so without the potential negative effects you can get from taking I3C. This molecule is so great for getting rid of excess estrogen that it’s often referred to as the “Estrogen Buster.” However, it’s not a complete story.
Learn more about taking DIM as a supplement in this short video:
Some Benefits of DIM
DIM is best known as a nutrient that supports healthy estrogen metabolism. It’s also known as a supplement that can help in the prevention of hormone-related cancers due to its anti-estrogenic and anti-androgenic effects. (6, 7)
Here are a few known benefits of DIM: (3)
- Supports Phase 1 liver detoxification
- Helps break down estrogen into “clean” estrogens, not the antagonistic “dirty” ones
- Promotes a healthy balance of testosterone and estrogen by preventing some testosterone from converting into estrogen. (acting as an aromatase inhibitor)
- Protects cells from the damaging effects of oxidation (working as an antioxidant).
All these benefits make DIM an attractive addition to one’s supplement regimen… That is until it stops working.
When DIM Stops Working. . . What’s Going On?
While DIM can be an effective supplement for some, it doesn’t work as well alone. In fact, you can feel worse after taking it if you’re taking it by itself. DIM needs the help of a couple of other nutrients to help it completely flush out the extra estrogen. Here’s what’s actually happening…
The way DIM works is through supporting only Phase I of liver detoxification. However, complete estrogen metabolism in the body requires support of both Phase 1 and Phase 2 liver detoxification pathways.
Liver detoxification is made up of two phases:
- Phase I is all about oxidation (basically, burning up toxins, used up estrogens, etc., with oxygen and enzymes).
- Phase II is conjugation (combining the oxidized toxins and used up hormones with other substances to make them less dangerous).
Phase II also makes the toxins water soluble, preparing them to be eliminated from the body through the bile or urine.
If DIM is used alone, it will help with Phase I liver detoxification, so the toxins and hormones will be oxidized (broken down) and made ready to be eliminated. However, without an active Phase II pathway, these oxidized toxins will get recirculated in the body, rather than being eliminated. (3)
This means that DIM only partially helps to remove metabolized estrogen from the body. It can also make you feel worse, because the toxins, used up hormones (estrogen), bile acids, get sent back through your body, creating inflammation and more imbalance.
That’s why DIM needs to be combined with two other nutrients, sulforaphane and calcium D-glucarate. These two nutrients help the liver complete the detoxification process and eliminate the excess estrogen from the body.
How Sulforaphane Works With DIM
Sulforaphane is an active component of cruciferous vegetables — and especially broccoli sprouts. You can certainly get some of it in your diet by including these foods. However, it’s difficult to know just how much sulforaphane is in each serving of broccoli or sprouts, because it varies widely. Again, that’s why a sulforaphane supplement could be helpful.
Sulforaphane works with DIM by additionally supporting Phase II of liver detoxification — specifically, the sulfation (sulphation) pathway, which is the main pathway for estrogen metabolism. (8)
After the estrogens are oxidized in phase I (along with thyroid hormones, environmental toxins, etc), sulfation helps to eliminate “dirty” estrogen metabolites by combining them with sulfur-based compounds, like sulforaphane. They are then water-soluble and are ready to be eliminated from the body via the kidneys and liver. I personally use and recommend Brocco Power, our sulforaphane supplement. The recommended dosage is 500 mg a day.
Sulforaphane also increases the “good”/protective estrogens, so that you maintain a healthy estrogen balance.
How Calcium D-Glucarate Works With DIM
Calcium is another powerful supplement that supports Phase II liver detoxification. (I actually took it before my surgery to help me detoxify better from all the medications they put me on. You can read about my pre- and post-surgery protocol here. But instead of the sulfation pathway, calcium d-glucarate works on the glucuronidation pathway of Phase II – another key pathway that metabolizes “dirty” estrogens.
The glucuronidation pathway uses glucaric acid (which is what calcium d-glucarate converts to) to bind toxins, including “spent” estrogens. Supplementing with calcium d-glucarate helps inhibit the production of an enzyme called beta-glucuronidase, which is produced in the gut. High levels of beta-glucuronidase are associated with breast, prostate, and colon cancers. (9)
Calcium d-glucarate helps keep metabolized estrogens from being reabsorbed. It also clears out the “dirty” estrogens that may be contributing to estrogen dominance.
The recommended dosage of Calcium D-Glucarate ranges from 150 mg to 300 mg per day. This supplement should be taken with meals for best absorption.
Precautions: Because Calcium d-glucarate can speed up the metabolism of toxins, it can also decrease the effectiveness of medications. So, if after talking to your doctor, you decide to take calcium d-glucarate, you might want to take it a few hours away from your medication(s).
You can learn more about calcium d-glucarate and how it helps with hormone balance by reading this article.
Overcome Estrogen Dominance With Help From This Kit
Based on the above research and positive experience of our community, I’ve put together a kit specifically for Estrogen Dominance. It’s called the Estrogen Reset Kit. It contains all 3 of the supplements you need to normalize your estrogen levels and get back to balance:
- Brocco Power is our Wellena branded sulforaphane supplement
- Calcium D-Glucarate
These three supplements used together offer complete estrogen metabolism and elimination. Taking this kit along with following a hormone balancing diet can massively speed up your recovery from estrogen dominance and its frustrating symptoms.
Precautions: Some research has shown that DIM could affect blood sugar levels. If you’ve been diagnosed with diabetes or hypoglycemia, or are taking drugs, herbs, or supplements that affect blood sugar, please talk to your healthcare provider before taking DIM. If you decide to add DIM to your supplement regimen, make sure your blood glucose levels are being monitored along the way.
Who Can Benefit From The Estrogen Reset Kit:
If you have any of the following issues, associated with Estrogen Dominance, you may benefit from the Estrogen Reset Kit:
- stubborn fat on the butt and thighs
- water retention
- weight gain, especially around the butt and hips
- tender, lumpy, or fibrocystic breasts
- heavy periods
- irregular periods
- lack of ovulation
- uterine polyps
- thyroid nodules
- estrogenic cancers, such as breast, ovarian, or uterine
Do any of these sound familiar? If so, this kit may be a piece of the (health) puzzle for you.
Where to Start
Where do you start if DIM stopped working for you? If budget is an issue right now, I’d recommend starting with a Sulforaphane supplement (Brocco Power). Then, if your symptoms don’t subside, I’d recommend adding back the DIM and also Calcium D-Glucarate.
That said, if you purchase all three of these supplements together as the Estrogen Reset Kit, rather than individually, it’s going to save you $33.83 – practically the cost of an additional supplement. So in the long run, getting the kit is the most efficient way to go — both in terms of cost and in terms of getting your Estrogen Balance under control.
Have you had this experience of DIM working and then not working when taking it by itself? Did you find Sulforaphane and Calcium D-glucarate to be helpful? Let us know in the comments below.
- Gong, Yixuan et al. “3,3′-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells.” Cancer research. 2006.
- Omar I. Vivar, Elise F. Saunier, Dale C. Leitman, Gary L. Firestone, Leonard F. Bjeldanes, Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane, Endocrinology. April 2010.
- Wszelaki, M. Overcoming Estrogen Dominance. New Type Publishing. 2020.
- Dalessandri, Kathie M et al. “Pilot study: effect of 3,3′-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.” Nutrition and cancer. 2004.
- Zahid, Muhammad et al. “The greater reactivity of estradiol-3,4-quinone vs estradiol-2,3-quinone with DNA in the formation of depurinating adducts: implications for tumor-initiating activity.” Chemical research in toxicology. 2006.
- Liu, Xiaojiao, and Kezhen Lv. “Cruciferous vegetables intake is inversely associated with risk of breast cancer: a meta-analysis.” Breast (Edinburgh, Scotland). 2013).
- Gee, Jason R et al. “Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.” European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2016.
- Xu, Yali et al. “Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.” Cancer science. 2012.
- “Calcium-D-glucarate.” Alternative medicine review : a journal of clinical therapeutic. 2002.
Thank you for the info.A bit confused.Always read that cruceferious veggies are not good the thyroid. .Would like to be part if your email subscription.Thank you for the good work.
Yes, the information on cruciferous vegetables is a bit confusing, and a misnomer that has been passed around the internet unfortunately! That’s why we put together an article on cruciferous vegetables specifically to help clear things up: https://hormonesbalance.com/articles/truth-cruciferous-thyroid-not-think/
I hope this is helpful to you. I added your email to our newsletter subscribers, so you should receive your first email from us soon. 🙂
Please get in touch if we can answer any other questions.
– HB Team
Good morning,I am a breast cancer patient, did chemo, did the breast surgery ,and I am going to do radiation ,after my Doctor will start me on Anastrozole ,my cancer is 95% estrogen,do you think Your estrogen reset kit will help?
Hi Lilieth! This question is best discussed with your health practitioner, especially in regards to taking alongside prescribed medication.
Here are a couple of other articles that might have some useful information for you:
Wishing you strength and health, the HB Team
I just finished radiation treatment on my breast cancer breast. And I am now 100% cancer free. My doctor also wanted to start me on a new relative of the medicine you’re mentioning there and I got extremely ill. Be sure and read all the side effects of the drug. I met with my oncologist, told him that I could not take that drug and I wanted to do a natural product. I was very pleased how open he was to listening to me, and he said in his 23 years of practice he’s never had anyone get ill like I did, but he was open to learning about them and the other products to balance my hormones because my tumor also is estrogen-based. I thought it was strange he was unaware of the side effects of the drug and had never heard of DIM. I look forward to trying these three products and finding a naturopathic doctor to work with.
I started taking DIM almost a month ago as per recommendation. I could see a huge change. No pms symptoms, only slight cramping, a lighter blood flow, higher energy levels. I still experienced spotting before the period. I’ve been suffering from painful periods and/ or endometriosis for my entire life (I’m almost 39), and it is all down to your book which I’d read over a year ago. I’ve been doing my own research and it’s beyond me how no one ever told me to approach the problem more holistically. Going from one gynecologist to another for years, the only “solutions” I was offered were the pill and strong painkillers. Thank you for your work.
We’re so honored to be a part of your healing journey, Gosia! It is incredible how difficult it can be to get this information from medical practitioners, and definitely part of our mission to make this information more accessible to women suffering from the many symptoms and conditions of imbalanced hormones.
– HB Team
This is my story too! Thank you for sharing.
Thank you so much for the info on the three phases. How does DIM affect the sugar levels? Does it increase or decrease?
Thank you kindly,
I’m in perimenopause, I entered when I was 40. Suffered all my life with weight gain issues. I don’t have a thyroid abd I’m insulin resistant and leptin resistant. I did a Dutch plus test and I’m deficient in progesterone abd though I’m really low in estrogen 14 level ( I get night sweats, hot flashes, dry skin, anxiety etc) My ratio is off abd considered estrogen dominant. Is it ok to take DIM? I’ve taken it in the past and immediately felt horrible within a day of starting it. Should I start with the sulforaphane? Could someone be allergic to sulfur? Should I replace my estrogen along. Do you have an article I can read about this? Thank you
Hi Jennifer. DIM supports Phase I of liver detoxification, and so some women can feel worse if they are just taking DIM. This is where sulforaphane (Brocco Power) and Calcium D-Glucarate come into play. If you have any allergy concerns, it’s important to talk to your health practitioner.
This article has more information about how these three supplements work together: https://hormonesbalance.com/articles/top-3-supplements-for-estrogen-dominance/
https://wellena.com/pages/wellena-estrogen-reset-kit When possible, we suggest taking these supplements in this order:
Start with: Brocco Power for 1-2 weeks
Add next: Calcium D-Glucarate
Add last: DIM
I hope this helps! Please reach out to [email protected] if we can answer any other questions or do more to support you.
– HB Team
Should I take all three supplements together or spread them out throughout the day? Thanks for your time.
Hi Tifani! Yes, you can take all three at the same time. If you are new to the Estrogen Reset Kit supplements (DIM, Brocco Power/sulforaphane, and Calcium D-Glucarate), it can help to introduce on at a time. The suggested regimen is Brocco Power, then Calcium D-Glucarate, and end with DIM.
– HB Team
Hi, Last year I was diagnosed with ER and PR positive invasive ductal carcinoma. Thankfully it was caught early and did not require chemo or radiation. I opted for a bilateral mastectomy with natural tissue reconstruction. I do not have to take any hormone medication. I have cleaned up my diet/life (with the help of Magdalena!) and have been taking the estrogen reset kit. I just upped my dose of Dim to two pills with two calcium D-Glucarate and one Brocco Power all at once after dinner. Is that a good way to take them?
Hi Tia. It’s great to hear you are making positive changes to your diet and lifestyle to support your health!
For the Estrogen Reset Kit, the suggested regimen is: 1 capsule DIM, 2 capsules Calcium D-Glucarate, 1 capsule Brocco Power. It’s a good idea to follow this regimen for a couple of months before increasing any dosages.
As for what time of day to take them, these supplements can be taken at any time of day, together or separate.
I hope this information helps. Please reach out to [email protected] with any additional questions.
– HB Team
I took calcium glucarate for about a year and worked wonderfully for my estrogen dominance. Then it stopped working. Is this because I wasn’t supplementing with DIM as well?
How do you know when to stop taking these supplements? Or are they meant to be used indefinitely to maintain balance?
Hi Gabi, many women do move on from using the three separate supplements once the majority of estrogen dominance symptoms have ceased. DIM and Calcium D-Glucarate are meant to be taken shorter term like 3-6 months. The Brocco Power can be taken long term. Wise Women’s Balance is another Wellena product that can be used for more for a maintenance supplement. I hope this helps. ~Kamalani HB Support
How do you know how long to take these three products especially when you’ve had cancer. The dr wanted me to be on medication five years. Any recommendations for finding a great naturopathic dr. What questions should I ask?
Hi Jan, this is a great question to ask a functional medicine doctor or naturopathic doctor who knows your health history and current numbers. If you are looking for a good naturopathic doctor, here is a great tool to help you with that. ~HB Support https://naturopathic.org/search/custom.asp?id=5613
Anxious for answers!
Sounds like this protocol would work for males as well?
Hi Allen, since men can still be estrogen dominance this protocol could be suitable. That said, you will want to consult with you practitioner first to determine whether this would be a good fit for you. It will work to lower all estrogen levels to help with rebalancing, so connecting your practitioner will be an important first steps. ~HB Support
Hi! I started Dim the first of October and 2 weeks later I ovulated on my own! I have PCOS so this is amazing!! However now I’m on cycle 2 and my body is struggling to ovulate. Is it because I didn’t take the other 2 along with it? Are these to be taken all together for long term?
I have 28 day cycles always have but since coming off the levlin pill birth control 5 years ago which I was on for 10years I have had really low energy elevated every month I’ll have two weeks of dragging my feet in my period and the week following. What info would I need to look into before taking the reset kit? Do I need to know 100% that I am estrogen dominant? Doctors have always told me they suspect I am ED.
My energy is debilitating and hard as I am a very active and fit person and can never keep consistency with my goals. My bloods always say I have great iron etc when I don’t take supplements.
Also do you ship to Australia 😇 I’m very hopeful that this can help
I have very high estrogen and hbg. Progesterone and testosterone are within normal limits. Will DIM help in eliminating the excess estrogen without affecting other hormones?
I already take DIM with no issues, I’m adding Broccoli power, how long before I notice a change ?
Hi Susie, this depends on your current liver function and what pathway needs support. There can be a large time range, but you can typically begin to notice changes within two to six months. ~HB Support
Hello. I’m wondering about the long term use of the products, long after detoxifying is complete. Will all three of these products need to be taken long term to keep things balanced?
Hi Emily, the DIM and Calcium D-Glucarate in the trio are meant to be taken shorter term like 3-6 months. The Brocco Power can be taken longer term. DIM and Calcium D-Glucarate will lower all estrogens, both the clean and the dirty, so it is best to use these items for a shorter period of time vs. long term. Brocco Power / Sulforaphane does not lower estrogens, but opens up the pathways of detoxification, and so can be taken long term. The DIM and Calcium D-Glucarate in the trio are meant to be taken shorter term like 3-6 months. The Brocco Power can be taken longer term.
I hope this helps! ~HB Support.
One other person asked this, but I couldn’t find anyone’s answer, so sorry for the repeat. I couldn’t find any information regarding the research for HOW DIM affect blood sugars, so I wondered if there are any links you could include for the research referred to and also is it said to increase or decrease blood sugars?
Hi Becka, these clinical trails show some interesting results in regards to the effect DIM has on blood sugar. But it’s important to note that this study was conducted with the intent of evaluating DIM for diabetic patients, not general blood sugar influences.
This research study also found interesting evidence that DIM may improve insulin sensitivity. Although this was not a human study, it does show promising results. https://pubmed.ncbi.nlm.nih.gov/29722480/
I hope this helps! ~HB Support
Can taking too much DIM and calcium d-glucarate (or taken for too long) cause missed periods due to their oestrogen-lowering effects?
Hi Donna, low estrogen can impact missed or irregular periods. This is an important hormone for the regularity of our periods. Taking DIM and Calcium D-Glucarate for a prolonged amount of time can lower our “clean” and “dirty” estrogens. Although there are many things that impact estrogen and menstruation, it’s important to take these supplements for a length that fits your bodies needs. I hope this helps. ~HB Support
Hi! I’ve recently found out I have an endometrioma (which I believe means I likely have endometriosis) after suffering with almost constant spotting between periods and a lack of ovulation. I’ve read that endo is usually caused by too much estrogen so I’ve just started taking DIM in the last two weeks to see if that helps. Just finished my period. and where it would usually be 6-7 days long and fairly heavy, it was only 3 days long and very light – day 3 wasn’t much more than what I’d say my spotting is like between periods. Is this normal? I didn’t realise DIM could alter what my period was like, I was just hoping it would help with spotting! I realise I’ve not been taking it long though…
Hi Jolee, DIM does has the potential to affect your period because it affects estrogen levels.
In Magdalena’s Overcoming Estrogen Dominance book, there is a whole protocol for endometriosis in that would be worth exploring. I hope this helps! ~HB Support.
I’ve recently started taking DIM and Calcium D Glucarate (another brand) and 2 weeks in I’ve developed what looks like hormonal acne.
Should I continue or stop? It’s so difficult to know when to push through.
Hi Sonia, acne can be seen as a detox symptoms while your body is detoxing the estrogen. You things to support your detox pathways to help this. Some options include:
Increase water intake – Drink half your body in ounces per day
Hot and cold contrast showering
Sauna – anything to make you sweat
Epsom salt baths
We hope this helps! ~HB Support
Hey there have been taking DIM for a few months and recently had much lower estrogen than normal almost in the menopausal level. Wondering if the DIM is causing that and if I should lower my dose or stop all together?
Hi Crystal, DIM will lower all estrogens, dirty and clean. So it’s typically recommended to use for a short amount of time, 3-6 months, unless otherwise directed by your healthcare practitioner. ~HB Support.
I’ve been taking dim over a year for hot flashes and now suddenly there back I am going to try the brocco powder .I will let you know how works .
Hi Jennifer, please note that DIM will lower all estrogens, dirty and clean. Since hot flashes are related to low estrogen, it’s important to support your bodies overall detoxification and liver function. Brocco Power will support phase II of your liver detoxification, and it’s best to use DIM for a short amount of time, 3-6 months, unless otherwise directed by your healthcare practitioner. ~HB Support.
I have low estrogen and also estrogen dominance. Would these supplements be right for me in terms of fertility? I do not want my estrogen levels to get lower than they are already.
Hi, the Estrogen Reset Kit not the best for low estrogen. These supplements can further lower estrogens. So if you are not yet clear on whether or not you have Estrogen Dominance, starting with a Dutch test could help you decide next steps.
The DUTCH test can help you gain additional insights and explore how your body is metabolizing estrogen. This can help guide you towards what food, herbs and supplements could support you. For hormone testing Magdalena refers people to https://hormonesbalance.com/articles/what-lab-tests-to-order-to-manage-your-hormones/
Although fertility is not our primary focus, our Overcoming Estrogen Dominance book is an excellent resource to work on balancing progesterone and estrogen, along with the other important aspects of hormone health. Here is a link for you:
It is important to consult with an integrative or functional practitioner to support you during this time. Wishing you well on your journey ahead. ~HB Support
I got debilitating headaches and felt terrible physically after taking DIM, is there any way to prevent this? Will taking a lower does help?
Hi, some find that when they start DIM, certain symptoms get worse. This is often due to the Phase 2 detoxification pathways being blocked. You could try supplements like Brocco Power and Calcium D-glucarate first which support Phase 2 detoxification. Once you open up Phase 2, then you could try DIM again, and see if your body does better with it. That said, not every supplement is going to work for everyone and it’s important to consider your individual needs while working with a supportive practitioner. ~HB Support.
What stops estrogen levels from rising back out of control when you stop taking dim and calcium d glucarate?
Hi Zoryanavira, great question! If while doing the supplementation you are also able to get to the root cause of why your hormones keep going out of balance, such as a high toxin burden, lowered digestive health, nutrient deficiencies, blood sugar problems or even inflammation, then when you come off, the reason why this happened in the first place would be fixed. This is one of the major reasons its so important to also be addressing the root cause while bringing your hormones back into balance. ~HB Support
Does anyone know why a temple throbbing like sensation on only one side of the head occurs when taking DIM Supreme with broccoli seed extract? I also took milk thistle 350 mg for three weeks hoping that sensation would subside as I loved how it helped my body but it didn’t so I stopped taking it. Any advice would help
Hi Angela, its possible that the dose is too high for you if you are experiencing these symptoms. In this case, try dropping the dose of both the DIM and the broccoli seed extract and start with one at a time. Try the broccoli Seed extract first for a few days and then if no issues, add in the lower dose of DIM and see how you feel. If DIM still bothers you, then you may just want to stick with the Broccoli seed extract which is just as wonderful a hormone supporter. ~HB Support
I was taking DIM for a few months, felt great but then started getting hot flashes and missed periods so I stopped. I think I lowered my estrogen too much. I’m not taking it anymore and im still getting hot flashes. I’m afraid I did permanent damage. Will my levels return back to normal? Is there anything I can do to correct this?
I struggle with surgical menopause Dizziness, I had a Hysterectomy and Bilateral oopherctomy 18 months ago, and have been dizzy ever since, someone has recommended that I take DIM, I dont really know much about it and is it safe to take with HRT?
I have had alsorts of tests done and everything is normal, so im wondering if it is the HRT?
Any help would be gratefully received, I just need my life back now.
Hi Leanne, DIM can be used with HRT, and can help with supporting proper estrogen metabolites reducing side effects from HRT. ~HB Support
I’m on MD Indolplex and after reading your article I asked my naturopath if I should be on Sulfuraphane.. She said no because Indolplex is not a direct form of DIM. I can’t help but wonder though……
Hi Shanna, Indoplex/DIM is not the same as sulforaphane. They function differently and in combination with one another to enhance estrogen metabolism. Sulforaphane works on enhancing the function of phase 1 and phase 2 detox pathways in the liver and in combination with DIM, which works to enhance phase 1 of the liver detox pathway for estrogen, they open up the two main liver pathways for estrogen detoxing. Check out our other article on DIM that explains how sulforaphane and calcium-d-glucarate work together to enhance estrogen detox. Hope this helps! https://hormonesbalance.com/articles/why-dim-alone-isnt-enough-for-estrogen-dominance/ ~HB Support
I wish i found your blog earlier so i can also buy your products! 🙁
So i have already bought DIM from another brand and its contains 100mg Indolplex® Diindolylmethane(BR-DIM® Complex, and 100mg Protectamins® Vegetable Blend
(spinach, broccoli, cabbage).
i took it for a week last week(just before bed) and have been getting headaches and then i came across your blog and realize DIM has to be taken with D Glucarate! So i stopped the DIM for a couple of days and now that my D-glucarate has arrived i was wondering should i just restart with D-glucarate for about 2 weeks before resuming my DIM, or just take them both together?
Thank you sososo much!
Hi Sophia, we recommend trying the Calcium-D-Glucarate first and then wait a few days before starting the DIM again and see if your body does better with that. ~HB Support
Hi there thank you for your reply! ❤️ really appreciate it
I have been suffering with hormonal imbalance and estrogen dominance for almost a year. Where should I start if I buy all three supplements? My most common symptoms are breast pain/lumps, decreased sex drive, fatigue, increased hunger and irregular periods/ovulation, mood swings. Sometimes lasting as long as three weeks. I eat fairly clean and occasionally exercise. But am at my wits end as it affects my day to day and fall under all the symptoms of estrogen dominance. I prefer natural supplements vs medication. Thanks!
Hi Maisa, if you think you are experiencing estrogen dominance, you can start doing all 3 supplements, Brocco Power, DIM and Calcium-D-Glucarate. We recommend starting slow with the Brocco Power for a week, then add in the Calcium-D-Glucarate for the next week and finally add in the DIM so you are taking all 3 supplements. This can help you adjust to the supplements and still start getting the benefits of the kit. ~HB Support
First at all, thank you very much for such great detailed article 🙂
I am thin but my tight and butt keep a lot of water retention and cellulite.
Last year I tried a progesterone cream that I rubbed on my tights . I used it 1-2 weeks and I had an perianal abscess and I had to have surgery to drain it.
4 months ago, I started taking DIM and I saw a lot of improvement in my legs and after 1 month of using it, I got another perianal abscess and had to have another surgery.
My question is,
Do you think the progesterone cream and/or the DIM supplement could be related to these infections?
I have looked for scientists papers and nothing but I don’t ti much of causality..
Thank you very much for your great work.
Hugs from Spain 🙂
Hi Elisabet, while we have not heard of this happening from progesterone creams of DIM, you may want to look into your digestive bacteria. If there is an imbalance in the digestive flora, hormonal changes could instigate inflammation and possible infections from bacteria already present. This typically occurs when blood sugars change as well. It would be important to get your digestive flora checked out and see if there is an opportunistic bacteria in there that could be leading to the perianal abscess. We hope this helps guide you in a good direction. ~HB Support
I am menopausal and have low estrogen. I will soon go on bio HRT. Do I just take the brocco powder to maintain clean estrogen and detox the dirty estrogens? Or is there a combination I should take to keep the clean estrogen?
Hi Jay, you can take just the Brocco Power to support your liver in detoxing the estrogen metabolites. If you needed more support than this due to low estrogen, you may want to look at adjusting your BHRT. ~HB Support
I’m 51 and still cycling heavily from adenomyosis, endometriosis, and fibroids (all estrogen dominant conditions, as I understand it). I’ve been taking DIM and I3C for months with no relief on the heavy bleeding. Are the other two products something I should add? Should I stop the DIM and I3C? Thanks for all of your efforts.
Hi Keka, if you are still experiencing hormonal imbalance issues even with DIM it is absolutely worth it to try adding in the Brocco Power and Calcium-D-Glucarate here. In addition, something like nattokinase, a proteolytic enzyme like in our Fibro Support, that can help with dissolving excess fibrous tissue such as what is found in fibroids, may be something else to look at. Hope this helps!~HB Support
I had stage 1 breast cancer with no lymph nodes involvement twice. First lumpectomy with no radiation or hormone aromatase treatment. I am 64 yrs old. I do not want to take tthe exemestane and have been on Dim and Calcium D glucarate for 7 months. I feel great. How do I know if this is working and should I add the Brocco Power? How can I measure my estrogen levels to see if this approach is helping me not have a recurrence of breast cancer?
Hi Catherine, the only for sure way to know if your levels are in a good range and the supplements are working is to have some good hormone labs done. We recommend working with a functional medicine practitioner and doing something like the DUTCH test which will give you those in depth answers of what your estrogen levels, types and metabolites look like and how they have changed. You can look into some information and a link to that test here: https://hormonesbalance.com/articles/what-lab-tests-to-order-to-manage-your-hormones/ I hope this guides you in a good direction! ~HB Support
Haven’t read everyone’s comments but curious. My dd is 14yo and had her appendix removed 4 months ago only to still have pain and now they say her gallbladder has to be removed. I have read quite a bit about hormonal imbalance affecting gallbladder. Is this something that I can try for my daughter?
Hi Concerned momma, hormones can play a role in gallbladder health so should be something to look at with her doctor. In addition, you may find this website on gallbladder issues really helpful. https://www.gallbladderattack.com/ Hope this helps! ~HB Support
I am on hrt using bio identical hormone cream with estrogen, progesterone, she’s and testosterone. I am 60 years old and had a hysterectomy when I was 40. I have been working with a NP the last 3 years. My NP wants to increase my estrogen based on blood work but every time I do my estrone levels increase and I have symptoms of estrogen dominance. I’ve tried DIM but it causes my fibromyalgia pain to increase. I’ve tried iodine, flax and other methods to try and decrease the estrone levels. They seem to work only slightly and only when I’m taking a lower dose of the cream than recommended. I’m going to try the reset protocol in hopes that I can get my estrogen levels where they should be. Any input you would have in regards to my situation would be appreciated. Thank you for your time and sharing your knowledge.
Hi Rosanne, you may want to check out our Brocco Power in addition to the DIM you are doing to help with the estrogen metabolite detoxing. Sometimes opening up those liver detox pathways can be just the addition needed to really help the DIM do its job. ~HB Support
I have been on Yasmin contraceptive pill for about 10 years. I have always suffered from mild hormonal acne but I read about DIM and starting taking these alongside my pill for the last 2 years and my skin has been perfect. I’ve now been told by my doctor to come off of Yasmin because if my age (I turned 40 in September). I carried on with DIM but I’ve noticed my skin has not been clear and I’ve had a couple of huge normal cysts. I have also had chest discomfort although I’m not sure if this is linked or not. Is it possible that DIM will not work now I’m not on Yasmin.. were they a good balance together but not now I’m not on Yasmin anymore? Can DIM cause any chest discomfort.? It feels like excess gas in my chest..
Hi Emma, sometimes it can take some time for your body to really adjust and come back to normal balance after birth control use. In the first 6 months after stopping, you can have a rebound effect where the body becomes even more imbalanced in an effort to relearn how to produce its own levels of hormones. Adding in Brocco Power which contains sulforaphane and even Calcium-D-Glucarate may be helpful through this time. In addition, you may want to look into the birth control detox here: https://drbrighten.com/post-birth-control-hormone-reset/ Hope this helps guide you where you need to be! ~HB Support
Two questions please!
1. Hysterectomy and on HRT cream. Can I take DIM? I’ve read on other sites that you shouldn’t when on HRT.
2. My daughter is 20 with terrible acne. I have no doubt she is estrogen dominant based on other symptoms. Can she take DIM? Should she take the other 2 supplements as well? Nothing we’ve tried has helped.
Hi Kristi, yes, you can take DIM on HRT as it supports the balancing of estrogen metabolites in the liver. And yes, if your daughter is dealing with hormonal acne, taking DIM alongside dietary changes to support her hormones and even possibly adding in Brocco Power and Calcium-D-Glucarate might be helpful in rebalancing those hormones and relieving her acne symptoms. ~HB Support
I had Hysterectomy in 2013 since then I have been on Estradiol patches ,…for the last 7 years I had a dose of 0.050 then 2 years ago my doctor lowered the dose 0.025 and add Replens Moisturizer bc I was dealing with headache, blood pressure,discomfort, pain and unbearable dryness .
Now I have the same symptoms. I stop using the patches and it’s getting worse.
I tried Dim and for dryness I was told to use Utrophin PMG.
Question: Is ok to use the Estradiol patches and Dim or the entire Kit together? Or I have to stop the patches and just do supplements?
Thank you in advance!
Hi Doina, yes it is safe to take DIM and HRT to help balance your estrogen metabolites. It’s also worth talking to your doctor or reaching out to a functional medicine doctor and asking about adding in topical progesterone. When taking estrogen HRT uninhibited and without balancing the progesterone, this can lead to estrogen dominance symptoms for sure which include what you mentioned you are experiencing. Hope this helps! ~HB Support
I tried Dim last year and it worked wonderfully at getting rid of lumpy breast tenderness, but it made cycle longer and my periods heavier so I stopped taking it and then my periods went back to normal but my breast tenderness came back. I just stumble upon on your protocol, do you think this would make any difference with the period issues?
Hi KT, It’s possible, you might try supporting Phase 2 detoxification first, and see how your body does with that. We would suggest looking at Brocco Power / sulforaphane to explore that. The beauty of that is, that it will support Phase 1 and Phase 2 detox, but now lower over all estrogens. Here is a link for you: https://wellena.com/collections/single-products/products/brocco-power-2-month HB Support
Hi, is the Estrogen Reset Kit ok to take if you are taking blood pressure medication? I suffer from endometriosis and was taken off the mini pill (Norethindrone) last January. Since then my endometriosis has returned along with an endometrioma and multiple cysts on my right ovary. I am looking to try and reduce the cysts, inflammation and progression of the endo naturally. I do not want to have to undergo another surgery and am hoping this kit will work. Any suggestions you may have for my situation would be much appreciated. Thank you!
Hi Renee, There are contraindications with Calcium D Glucarate for some medications, as it increases the speed they are metabolized. So that said we do recommend you reach out to your practitioner to check and see what would be right for you. Here is an article where you can learn more: https://hormonesbalance.com/articles/role-of-calcium-d-glucarate-in-hormone-balance/ HB Support
Thank you for this long article with all the helpful information!
I thought I did enough research on DIM but I clearly didn’t.. For the last 3 weeks I’ve been taking a DIM complex supplement, which does not contain DIM.. It has 400mg I3C. It also has 150mg broccoli extract (0,5% sulforaphane), 50mg mustard seed extract and 50mg white cabbage extract. (and also NAC, black pepper and zink).
Now I’m not sure if I should continue taking this supplement.. (it’s 60 caps for 2 months). And do I need to add more broccoli/sulforaphane with another supplement?
Hi Aisha, while we can’t comment on other companies products, it does sound like you are on a sulphoraphane based product. Here is a link to our article on how sulphoraphane works, so you might research how it is working for you: https://hormonesbalance.com/articles/how-to-grow-broccoli-sprouts/ HB Support
I’ve been struggling to establish hormonal balance since going through medically-induced menopause 3 years ago. In my almost 2 years on topical BHRT, my estrone levels have consistently risen too high, despite continuing hot flashes at night. Obviously raising the estrogen dose to try to eliminate hot flashes just worsens the estrone buildup. I have also been taking a relatively high dose of topical progesterone, but my blood levels are lower than would be expected. My doctor recommended I start taking DIM and Ca D-glucarate, but as soon as I started them, I started spotting. He said to stick with it in hopes that my body will establish a new equilibrium, but that I will probably need to stay on them the entire time I’m on BHRT. However, I have read elsewhere that Ca D-glucarate, in particular, affects all steroids in the body and shouldn’t be taken long-term.
I would appreciate any insight you might have on these issues.
Hi Helen, While we can’t say what is right for you per se. You might explore how your BHRT is working for you, and if you need to look at a different type? For example some options like Biest can increase estrone levels, rather than estradiol levels (the one we want to increase). So you might start there by exploring that. CDG does lower all estrogens in the body, so it is recommended to only take shorter term. Here is an article that may help further: https://hormonesbalance.com/articles/role-of-calcium-d-glucarate-in-hormone-balance/ HB Support
I’m a male who takes finasteride which has resulted in excess estrogens. Will this product combination cause any issues in relation to my DHT blocker (finasteride)?
Hi Kyle, we are not medical professionals, so can’t advise if it would cause issues, but will suggest you reach out to your practitioner to talk it over to see what would be best for you. HB Support
Hi, I started taking DIM 2 weeks ago because I have very heavy painful periods, along with other symptoms that point to an imbalance in hormones. I also have hashimoto’s. My periods are always heavy, but never over 7 days and since taking DIM I have been on my period for 15 days now. In your opinion, should I add one of the other two supplements, or is this a sign that I am not estrogen dominant? I am willing to stick with it if this is maybe just my body adjusting. Thank you!
Hi Liz, whenever someone has an opposite reaction to DIM we think of how DIM on its own can sometimes not be enough to open the estrogen detox pathways and can lead to opposite symptoms. In such cases adding in sulforaphane and calcium-d-glucarate would be important to look at for options. In addition, if this is new, it would also warrant a check-in with your gynecologist to make sure there is not another possible reason for this excessive bleed. ~HB Support
Hi! I was taking DIM and it cleared up my hormonal acne within a few days and the results lasted about 3.5 weeks then my acne came back again and even worse. Is this because of phase 2 and my liver not detoxifying? Can phase 1 last that long before having issues in phase 2?
Hi Amanda, yes this can happen if your phase 2 is working but is not working fast enough. eventually there becomes a bottle-neck effect. Try supporting with some sulforaphane like in our Brocco Power along with the DIM and this may be the trick! ~HB Support
I have been suffering with hormone imbalance for almost 3 years now, I’m 35.
2 weeks leading up to my period I have very painful breast tenderness and a lot of water retention, especially my thighs. Some months I having insomnia and even night sweats.
I started supplementing with CDG 2 month ago and after 2 weeks I added DIM and broccoli sprouts.
I feel amazing, much more energised than usual. No PMS symptoms or moodiness this month.
I have a pretty regular cycle, usually 28-30 days but now I started spotting on day 23. Today I’m on day 46 and still no period. This last 7 days have had some mild cramps, sore nipples and a higher body temperature, especially in the evening.
Is it a common thing to have delayed periods/ovulation when starting CDG, DIM and broccoli sprouts? Can it be that the body is adjusting?
Should I continue with the supplements or stop them all together?
Yes, these supplements can absolutely shift your cycle days. Think of them like a reset button. They are opening up your detox pathways, likely shifting your estrogen levels, all which will have an effect on your cycle timing and length. It usually takes a few months to regulate your cycle on them. One word of caution is that DIM and CDG will lower overall estrogens, not just the dirty ones, so this is why we suggest this two for a shorter period if time like 3-6 months. If you are close to perimenopause or menopause we would suggest taking it one month at a time to make sure estrogen levels don’t get too low. Take care! HB Support
This article is so helpful!
Can the cycle of estrogen dominance keep going years after stopping birth control, even with all other external sources of estrogen removed? It seems that the pill was my most influential factor and I’ve been off for 15 years, yet have struggled with high estrogen symptoms ever since. You would think the body would self-regulate by then! :O Thankful for these supplements.
Fortunately, I’ve been taking the CDG for a month and can already feel benefits, however my clockwork 27 day cycle is a week late. Perhaps I should lower the dose? Pregnancy test is negative – CDG wouldn’t mess with HCG, by chance, would it? Lastly, on that note, is it best to avoid this supplement if trying to conceive?
Thanks so much for your time and for helping everyone in here with questions! <3
Hi Kat, the effects of birth control can last years with dips and peaks of hormones being balanced and imbalanced due to how birth control alters the brain to adrenal to ovary communication system. The other thing is, when initially starting supplements working with hormones, your period and cycle may alter for a couple cycles until leveling out around the 3rd cycle in most cases. CDG does not interact with HCG. Typically we do recommend avoiding DIM and CDG if you are trying to conceive or pregnant as it can alter your hormones and their natural rhythm if pregnancy is achieved. ~HB Support
Thank you for the reply, Stephanie! This all makes so much sense.
Hi! I’m 31 years old and have been taking 50mg (lowered from 100mg after feeling too dehydrated) of spironolactone for hormonal acne for about two years now. Around the same time my gyno suggested I may have PCOS due to quite a few matching symptoms, but progesterone only birth control affected me terribly so I have not been on any BC since then. My periods have always been extremely heavy, painful, and frequent – really the only thing that has changed that was being on the keto diet, but that is very hard to maintain. Almost a full month ago I began taking DIM 100mg. Since then my acne has gotten worse, I am losing way more hair than normal, and overall I don’t feel well. I understand this may mean I need to take sulphuraphane and CDG to support Phase 2, but since Ive already been taking DIM can I just add those in or should I stop the DIM and start over as suggested?
Hi Lindsay, while we can’t say what is right for you specifically, here are some things you can research and see what is right for you. If you are not feeling well, we would suggest evaluating what you are taking and back off from that place. Maybe stopping some items. The Liver detox works in reverse order, so you want to support Phase 2 first, so that you can open the door for phase one. You could try sulforaphane first as it does not lower all estrogens, and see how you feel. If you need to also remove toxins, you might add in Calcium D Glucarate to see if it is needed. You could then try adding DIM, to see if you need that support as well. Keep in mind CDG and DIM lower all estrogens, not just the bad ones, so these are meant to be used short term. Go slow, and find what is right for your body. I hope that helps! HB Support
I’m 46 years old and have been taking dim in different forms for a least 8 years.
On and off. I have endometriosis and have always treated it naturally. With a strict diet, a lot of exercise and different supplements. I have currently been taking a form of dim, with calcium d-glucarate and polygonum cupsidatum root extract, brassica oleracea and red clover. It is a very good product and has kept my period regular and reduced my crippling pms symptoms. I gave myself a break from it for six weeks and my period arrived 10 days late as well horrendous pms symptoms. Now that the period is over I still have pms symptoms (severe bloating and weight gain)and my breasts are so swollen and sore. I am my wits end and don’t know what to do. Could you please advise. I’m more than happy to try your supplements but am worried I have destroyed my estrogen levels. Would just taking the broccoli powder and calcium glucarate help? Estogen dominance and period weight gain have destroyed my life.Thank you and kind Regards
Hi Jane, We are so sorry to hear you are going through this. We would recommend working with a functional medicine practitioner to get to the bottom of the issues you are having. Here is a link to find someone that you resonate with. https://www.ifm.org/find-a-practitioner/
Jen @ HB Support
How long does one have to be on all 3 of these supplements – indefinitely or until symptoms get better?
I am happy to help you. Usually around 3-6 months is a good amount of time. We recommend trying for one month, evaluating how you feel and continue if you are still working through symptoms. I hope that helps. HB Support
Does the DIM works with Calcium D-Glucarate only? I mean, does the detox phase happens if I add only the calcium? It’s really hard to find Sulforaphane where I live.
DIM can work on its own without needing to take Calcium-D-Glucarate or even sulforaphane. In some women, it can function well all on its own. This article only brings to light that if someone responds poorly to DIM, it may just mean they need added supports but there are still situations where someone may respond perfectly fine to just the DIM. HB Support
I can’t believe you’ve been answering the comments for two years! I think I pretty much read them all… can you opt to take the 3 supplements for the first half or second half of your cycle?
I am in peri-menapause with high estrogen. Did the DUTCH test. My dirty estrogen was high. My liver wasn’t metabolizing well. I also had a severe ovarian cyst eruption that put me in the hospital with sepsis. Fun times. Prescribed DIM and Glutathione. I took for 26 days. I normally had 36-42 day cycle prior to this life transition but the 26 days of the two supplements dropped me to a 24 day cycle. I thought well that sucks so I stopped. 🙈 However, my cycles continued to get longer and longer. It was a bit of a roller coaster. The first half the cycles I felt amazing and high as kite (all good stuff) the second half of my cycles I was way low and don’t feel like myself. Since cycles are longer, I can feel great for 3 weeks or so and terrible for 3. I have estrogen dominant symptoms approaching menstruation. So I said ok I’ll go back on DIM and Glutathione. My high was not as high, my low was not as low and my approaching menstruation symptoms remained but were shortened greatly around day 23 ish. Then nothing, no period. 🤦♀️. Oh the let down of that anticipation. Eeesh. So can you take it for a section, or part, of a cycle? What does that do?