January 27th, 2022 | Posted By: Magdalena Wszelaki | Posted in Articles, Estrogen Dominance, Menopause

Estrogen Dominance in Peri- and Menopause

Estrogen Dominance in Peri- and Menopause

What You Will Learn in This Article 

  • Why women think Estrogen Dominance doesn’t make sense in menopause
  • Sharing my experience with Estrogen Dominance
  • The demographics of Estrogen Dominance
  • How it’s possible to have Estrogen Dominance during peri- and menopause
  • What you can do

Estrogen Dominance in perimenopause or menopause? You might be surprised to hear this is even possible. 

Most women, understandably, believe that if they have low estrogen, they couldn’t possibly have Estrogen Dominance. After all, it seems like a contradiction that you could be estrogen dominant while your estrogen levels are declining or are already low…

In this article, I will explain why it is possible, and even more dangerous to have Estrogen Dominance in peri- and menopause than it is during reproductive years when we have a lot of estrogen circulating in our bodies.

We’ll talk about how that happens. But first, here’s my experience with Estrogen Dominance.  

My Story And Interest in Estrogen Dominance 

As it often happens, when you go through a medical problem and come out on the other end, you want to share it with the rest of the world. In my case, first, it was Hashimoto’s thyroiditis and then Estrogen Dominance. I’ve managed to reverse both conditions well enough to feel and look pretty good for a 50-year-old woman. 

I’m now also going through perimenopause and armed with the knowledge I’ve gained over the years, I’ve definitely noticed that if I don’t stick with the diet and supplement protocols I’ve created, I feel the effects and my Estrogen Dominance symptoms return pretty quickly.  

I often see them being particularly pronounced when I travel, especially to Europe where I tend to indulge a little more in varied foods, more gluten (which I typically don’t eat at home, in the US), more wine and beer, later dinners and less exercise. And most importantly, I often forget to take my supplements. 

Now, given, I have a few genetic SNPs that predispose me to Estrogen Dominance – I’m a poor methylator and tend to recirculate “dirty” estrogens. This partly explains why so many women on both sides of my family have struggled with this hormonal imbalance and many have passed away from estrogenic cancers (uterine, breast, and ovarian cancers).  

What I have learned is that as I get older, enter peri-menopause, and experience declining hormones, my Estrogen Dominance isn’t getting better – it’s only getting worse. 

So yes, this is just how my hormones are, with these genes, predispositions and what not – and I’ve learned to live a lifestyle that feels fulfilling and rich, free of fear and frustration and somehow also made it my mission to help women reverse and manage Estrogen Dominance so they can live their best lives yet. 

My point is: do something early to address your symptoms, especially when in peri- or menopause. 

The Demographics of Estrogen Dominance 

As you ponder whether it’s possible to have Estrogen Dominance while you also have low estrogen levels, here are a few stats to consider:

  • The highest demographic of women who get estrogen receptor-positive (ER+) breast cancer (ages 45-65) are LOW in estrogen
  • The highest demographic of women who get ovarian cancers (ages 45-65) are also LOW in estrogen

Both ER+ breast cancer and ovarian cancer are due to Estrogen Dominance. If Estrogen Dominance didn’t happen in menopause, these estrogen-related cancers couldn’t happen. 

So, what’s going on? It’s not that there’s too much estrogen in these cases; it’s the hormone ratios and metabolism of estrogen that are the issues.

There Are Two Main Causes of Estrogen Dominance in Peri- and Menopause

#1 The Ratio of Estrogen to Progesterone is Off

This happens when you don’t have enough progesterone to balance out the aggressive estradiol (E2). This can happen even if both estrogen and progesterone levels are low – as happens in peri- and menopause.

As soon as we hit 40 or so, both estrogen and progesterone levels start declining quickly. 

The problem is that progesterone starts dropping a lot faster than estrogen does as we age. This creates an imbalance between the two hormones, leading to Estrogen Dominance.

Here’s a chart that explains: 

As you can see in the above chart, a 35-year old woman’s estrogen-to-progesterone ratio is pretty balanced. As both hormones decline, by the time she’s 55, her estrogen-to-progesterone level has shifted to estrogen being more dominant and progesterone being insufficient to oppose and balance out estrogen. 

Estrogen and progesterone work as “balanced partners.” They both play a role in fertility, beauty, mood, and overall health and vitality. However, progesterone is really there to oppose estrogen. 

Estrogen tends to have a more aggressive effect on the body, and progesterone is there to calm it. But both hormones work to keep the body in balance. 

Progesterone dropping a lot faster compared to estrogen creates a type of imbalance where estrogen becomes overly dominant. This is what leads to Estrogen Dominance and sometimes estrogen-related cancers.

#2 There’s an Issue With Breaking Down Estrogen Into Clean & “Dirty” Estrogens

Most of us have gone through a romantic or professional breakup that was less than ideal and the consequences lingered on. In the context of hormones, the liver is responsible for breaking down estradiol and estrone into smaller pieces as the first step in the process of eliminating metabolized or “dirty” estrogen. There are three different smaller pieces that estrogen can be broken down into: 

  •       2-hydroxyestrone (2-OH): a “good” estrogen that does not stimulate cell growth and can block the action of stronger, potentially cancer-causing estrogens.
  •       4-hydroxyestrone (4-OH): potentially harmful, with increased estrogenic activity. A “dirty” estrogen.
  •       16-alpha-hydroxyestrone (16-OH): potentially harmful, associated with an increased risk of breast cancer. A “dirty” estrogen.

 

We want more 2-OH with limited amounts of 4-OH and 16-OH. If that’s not happening because your liver is already taxed and therefore not able to break down the estrogens to eliminate them properly, it will generate too many “dirty” estrogens, so you’ll experience estrogen dominance. This is why the health of the liver is so vital when you’re experiencing estrogen dominance. 

Not surprisingly, as we age, our liver becomes less efficient than it was when we were younger. 

For example: In college, you could have, like, 5 shots of tequila, go to bed, and then get up, have some coffee and go to class. Try having 5 tequilas now and see how you feel in the morning! 

This is largely due to the fact that the liver just isn’t as efficient and effective at peri- and menopause as it was when we were in our 20s and 30s. 

This doesn’t just apply to the liver’s metabolism of alcohol, but also to its metabolism of hormones. Read more about the liver’s role in hormone balance here

The gut is another organ to address if you’re not metabolizing estrogen well.  Certain estrogen-metabolizing bacteria, collectively known as the “estrobolome” are there to keep hormone levels in balance. 

If they are damaged, for a variety of reasons (antibiotic use, toxins, etc), they won’t be able to properly break down estrogen, leading to Estrogen Dominance. 

 

Bottom Line 

You may have low estrogen levels, but that doesn’t mean you won’t have Estrogen Dominance.

 

What You Can Do

If you’re in peri- or menopause and you have symptoms of Estrogen Dominance, there are some things you can do:

#1 Take the Estrogen Dominance Quiz. Estrogen dominance symptoms occur in 75% of women, but the vast majority (90%) don’t even realize they have it. Take the quiz to find out for yourself here.

#2 Consider getting my book: Overcoming Estrogen Dominance. It will guide you, step by step, in how to eat, which supplements to take, and what lifestyle hacks to include in order to overcome Estrogen Dominance and get back into hormone balance.

#3 Start off with a few articles. While you’re waiting for your copy of the book to arrive, take a look at these articles: 

Conclusion

Going through peri- and menopause doesn’t exclude women from having Estrogen Dominance. In fact, Estrogen Dominance in menopause is even more dangerous than in reproductive years as women tend to produce more “dirty” estrogen that can be harmful. 

The GOOD NEWS is that Estrogen Dominance is highly reversible and manageable. It’s just a matter of getting started. We’ve provided some resources to get started under “What You Can Do” above – and if you need more, reach out to our team at [email protected]

27 Comments to Estrogen Dominance in Peri- and Menopause

    • Seems like nobody wants to talk to us ladies that have had a hysterectomy and have to live with bad hot flashes the rest of their lives. We are out there also

      • I have her book Overcoming Estrogen Dominance and I love it! The layout is perfect in that you can look up your questions by symptoms like: postmenopausal hot flashes, PCOS symptoms, heavy periods, light periods, migraines…. it’s really easy to navigate through and then it tells you what she recommends to eat towards better health and supplement towards balance. In addtion to taking everyone through the detoxification process to clean up the excess estrogen, which I believe is a very important step to alleviating a lot of the symptoms not enough practitioners address. I think she is amazing careful guide that has really understands the steps to take you out of the hot flashes and imbalance and toward feeling so much better.

      • I feel the same way. I had a complete hysterectomy at 42, I’m now 53 and my doctor is weaning me off of the estrogen patch. I have approximately 4 months and I’ll have nothing.
        What do I do then? What can I take to relieve my symptoms?

  1. Hello,

    Thank you for this article, but it is incomplete. You indicated in your email, that it would include a “What you can do” section.

    Thank you.

  2. Yes,great to know,but what can you do to rid the body of estrogen dominance?

  3. It’s highly reversible but how do we do it? I’d like to find more information about it. Thanks

  4. Great information but where’s the rest of the story. The last bullet on your list of topics to be covered is What you can do.

  5. I agree with all the other comments… good but misrepresented and incomplete article. Can you share what was promised as to what to do about it???

  6. Wondering what we can do as well? Is that another blog? Or did this one get cut off? TY!

    • I am glad she is on a mission to educate us. I would love to have my N
      M.D. know ANY of this. My history is exactly like hers! Lost my only sis at age 50 to this estrogen positive breast cancer. If she had known in her early 30s how to correct it I would still have her and her 4 kids would still have their mom.

    • Do you know anyone who gives away their expertise? We all have to eat…. Magdalena has poured herself into not only healing herself, but making the information available to all of us. You certainly won’t get it from your allopathic doctors.

  7. What if you have had a total hysterectomy? Is it still possible to have estrogen dominance? I’m 70 and have bad hot flashes, especially during the night.

  8. Go up to the top right corner wjere the little lines are and tap it. Then it will show you books and articles to answer it.

  9. I had estrogen positive breast cancer at the age of 41.. trying to find out what to do so it does not come back

  10. Sincere appreciation for all your expertise.

    It seems epigenetics has a major impact on ED.

    My results show I can’t breakdown estrogen nor histamine (which if too high exacerbates ED symptoms).

    I have followed all your treatment recommendations, yet, I am bedridden, devoid of energy along with many other ED symptoms if I eat food with phytoestrogens.

    I am 56, suffering debilitating symptoms for more than 10 years.
    Gynaecologists have been most in-helpful.

  11. Hi everyone, regarding what the next steps are to reverse Estrogen Dominance through peri-menopause and menopause, the links included in the “What You Can Do” section will be the best place to start. Since this a large topic to unpack, we’ve included links to Magdalena’s book, Overcoming Estrogen Dominance, and articles for more information. These will provide a thorough background and guide into what you can do to support your hormones through this transitional time if your life. I hope this helps! ~HB Support.

  12. Eating RAW carrots and other root vegetables that are high in indigestible fibre (that fibre becomes digestible when cooked) is a great and easy hack/ way to pull estrogen out of the body, via the digestive tract, where it is excreted. high fibre veg like celery and broccoli, cauliflower and brussel sprouts are also helpful. I’ve suffered from PMS migraines my whole life due to imbalanced hormones and this fibre hack has been a huge help. I usually start eating these on day 17-28 and increase the protein vs carbs in the first half of my cycle. There’s research out there on this-
    Hope that helps someone. <3

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